Top Nitric Oxide Boosters: The Best NO2 Supplements for Your Fitness Goals

By the Gym Floor Guide Editorial Team

Disclosure: This article may contain affiliate links. If you click a link and make a purchase, we may receive a commission at no additional cost to you. All opinions remain our own.

Nitric oxide supplements provide your body with essential nutrients and amino acids to enhance oxygen circulation and improve overall well-being.

Many nitric oxide supplements are available on the market that you can consume to avail benefits. Our team has compiled this article's best nitric oxide supplements.

Which Are The Highest Ranking Nitric Oxide Supplements?

Before we move on to the details of different nitric oxide supplements, we must understand that not all nitric oxide supplements work. Our team carefully reviewed and scanned reports to find the best nitric oxide boosters for you. Let's have a look!

• CrazyBulk NO2 Max (no longer listed)
• Juvenon BloodFlow-7 Nitric Oxide Booster
• Advanced BioNutritionals CircO2
• New Alpha Nutrition Alpha Strength
• VigRX Nitric Oxide
• Onnit Total Nitric Oxide
• Transparent Labs Strength Series Nitric Oxide
• Huge Supplements Magnify
• Old School Labs Vintage Burst
• Cellucor NO3 Chrome
• Snap Supplements Nitric Oxide Booster
• HumanN Neo40 NO2 Booster
• Sovereignty Purpose
• 1MD CardioFitMD
• NitriLean (official store offline)
• Brutal Force IBUTALEAN (out of stock)
• Brutal Force CARDALEAN (no longer listed)
• Drachen
• Rasputin Herbs Siberian Green
• The 20 Flow
• Anabolic Running
• Hyperbolic Stretching

CrazyBulk NO2 Max: No Longer Listed

• Availability: CrazyBulk no longer lists NO2 Max. Its product page returns “404 Not Found”, and none of the 24 products in CrazyBulk's store today has “nitric”, “NO2” or “pump” in its name (checked October 22, 2026).
• Price and refund terms: removed, because they described a product you can no longer order from CrazyBulk.

CrazyBulk NO2 Max used to sit at the top of this list as an amino acid formula for blood flow and oxygen supply during workouts. Since CrazyBulk has dropped it, the strongest nitric oxide pick for workout pumps and endurance is now the next one on this list, Juvenon BloodFlow-7, followed by the rest of the boosters below.

If you would rather stay with CrazyBulk, our old NO2 Max link now opens CrazyBulk Testo-Max. CrazyBulk says Testo-Max uses D-aspartic acid, magnesium, zinc, and vitamins D, B6 and K1 for strength, stamina and fast recovery, and lists it at $64.99 for a one-month supply. CrazyBulk presents it as a testosterone-support formula, not a nitric oxide booster, so pick it for strength training rather than for blood flow.

Juvenon BloodFlow-7 Nitric Oxide Booster

• Key Ingredients: L-arginine, L-citrulline, and others.
• Money-Back Guarantee: 90-day money-back guarantee.
• Pricing: It starts at $39.95.
• What's Unique About It: This supplement can increase nitric oxide levels by pushing oxygen in and throwing waste out of your body.

If you want to experience endless energy and youthful stamina, it is the best nitric oxide supplement. Juvenon BloodFlow-7 Nitric Oxide Booster can help you become the most vibrant version of yourself, even if you are 40.

This nitric oxide boosting supplement can revitalize your cells by increasing blood and oxygen supply. It is among the few that also target mental clarity.

This supplement is formulated by a famous doctor who has spent years researching the formula of Juvenon BloodFlow-7 and fellow medical professionals.

Juvenon BloodFlow-7 can help in boosting nitric oxide production with the help of amino acids and herbal extracts. This supplement can support quick muscle recovery so that you can participate in explosive workouts now and then.

Advanced BioNutritionals CircO2

• Key Ingredients: Vitamin B12, Vitamin C, Beetroot powder, and others.
• Money-Back Guarantee: 90-day money-back guarantee.
• Pricing: It starts at $49.95.
• What's Unique About It: This supplement can improve signaling between cells by providing oxygen circulation support.

Advanced BioNutritionals maintains close relations with its manufacturers and suppliers to ensure the usage of quality ingredients in all its supplements.

Advanced BioNutritionals CircO2 uses a blend of a solid amino acid profile, vitamins, and natural ingredients to enhance nitric oxide production in your body. It widens and relaxes your blood vessels so that you experience improved blood flow in your body. This supplement can replenish cells to help increase nitric oxide levels.

This natural nitric oxide supplement is vital for aged individuals with low nitric oxide levels. It is built to support healthy circulation and overall well-being.

Every pack of Advanced BioNutritionals CircO2 contains 30 easily dissolvable nitric oxide pills.

New Alpha Nutrition Alpha Strength is suitable for men who want to improve male health function and enjoy better physical stamina. New Alpha Nutrition Alpha Strength combines the power of eight science-backed super nutrients (including vitamins and amino acids) that have been studied for its potential to tackle low nitric oxide levels.

It is one of the few nitric oxide supplements on our list that also boosts testosterone levels so that men can enjoy multiple health benefits. It improves blood flow to the male organs and relaxes the vessels to help increase nitric oxide production.

This supplement is built to support healthy blood flow and fight fatigue so that you can follow a strict exercise regime. It is also the best for muscle recovery and enhanced exercise endurance.

VigRX Nitric Oxide

• Key Ingredients: L-Citrulline and L-Arginine.
• Money-Back Guarantee: 67-day money-back guarantee.
• Pricing: It starts at $59.95/bottle.
• What's Unique About It: This nitric oxide supplement widens and relaxes your blood vessels for better blood flow and oxygen circulation.

VigRX Nitric Oxide is the best nitric oxide supplement to improve your body strength without subjecting your body to injections, pumps, or artificial stimulants. This supplement can increase NO levels and boost overall well-being.

VigRX's nitric oxide supplements provide your body with essential nutrients that can rejuvenate your cells and enhance your oxygen supply. VigRX Nitric Oxide uses a solid amino acid profile and several research-backed natural ingredients in its formulation.

Besides boosting nitric oxide production, this supplement is designed to support the health of your immune system.

Onnit Total Nitric Oxide

Key Ingredients: L-arginine and L-citrulline, Mango fruit powder, and others.

Money-Back Guarantee: 90-day money-back guarantee.

Pricing: It starts at $39.99.

What's Unique About It: Onnit Total Nitric Oxide can help you quickly overcome exhaustion and support healthy blood flow.

Experts design the Onnit Total Nitric Oxide supplement to increase NO production. Onnit Total Nitric Oxide promotes muscle recovery, growth, and development.

Onnit Total Nitric Oxide contains organic ingredients and amino acids in its formulation to get your body to produce nitric oxide on its own. Onnit Total Nitric Oxide can improve blood flow by widening blood vessels so that more oxygen reaches every part of your body.

Onnit Total Nitric Oxide is a strong pick for people who feel fatigued and want more nitric oxide support. You will find only high-quality ingredients in the Onnit Total Nitric Oxide supplement. The Onnit Total Nitric Oxide formula is free from gluten, nuts, caffeine, and soy.

Many users have called Onnit Total Nitric Oxide one of the best in their reviews online.

Transparent Labs Strength Series Nitric Oxide is a clinically-dosed nitric oxide activator with a solid amino acid profile. The Transparent Labs Nitric Oxide supplement delivers L-arginine nitrate to your body to enhance muscle pumps and exercise endurance.

Every bottle of Transparent Labs Nitric Oxide contains 120 capsules. You must take four capsules daily to increase nitric oxide levels in your body.

The formula of Transparent Labs Nitric Oxide is free from artificial sweeteners, colors, and preservatives. It is among the best to relax and dilate vessels to improve blood flow.

Transparent Labs Nitric Oxide can enhance nitric oxide production and support muscle recovery and growth after intensive workouts. It also supports healthy blood flow during training.

Huge Supplements Magnify

• Key Ingredients: L-arginine, Beetroot extract, L-citrulline, and others.
• Money-Back Guarantee: 14-day money-back guarantee.
• Pricing: It starts at $44.95.
• What's Unique About It: This supplement can increase nitric oxide levels in your body and support healthy blood flow.

If you want to enhance your physical performance in every aspect of life, Huge Supplements Magnify is one of our list's best nitric oxide supplements. This supplement uses science-backed ingredients, including amino acids and vitamins, to target low nitric oxide levels in your body.

This supplement helps increase nitric oxide production to improve blood flow. It helps replenish cells that carry more oxygen to different organs. Huge Supplements Magnify can enhance muscle recovery, growth, and development so that you can participate in intensive workouts.

It is a budget nitric oxide supplement for which you don't have to spend much of your money.

Old School Labs Vintage Burst

• Key Ingredients: L-arginine, Maca root extract, Coffea Arabica, and others.
• Money-Back Guarantee: 100% refund guarantee.
• Pricing: It starts at $49.99.
• What's Unique About It: It is one of the few nitric oxide supplements that uses caffeine to increase your energy levels.

Experts formulate Old School Labs Vintage Burst to keep your energy levels high for hours. It can relax and dilate your blood vessels to experience better blood flow.

It is free from artificial ingredients, gluten, GMOs, and stimulants, so it suits people who avoid stimulants. Its formula is built from natural ingredients for daily use.

It can help increase nitric oxide levels using a solid amino acid profile. Old School Labs Vintage Burst is one of the best nitric oxide supplements that can enhance the oxygen supply to your working muscles.

If you want to experience health benefits while boosting nitric oxide production in your body, this is the right choice for you.

Cellucor NO3 Chrome

• Key Ingredients: Vitamin C, L-arginine nitrate, and others.
• Money-Back Guarantee: 60-day return policy.
• Pricing: It starts at $23.09.
• What's Unique About It: This supplement increases muscle blood supply by replenishing the cells with essential nutrients.

Cellucor NO3 Chrome is a natural nitric oxide supplement that uses organic ingredients and amino acids to target your overall health. It is among the best because it uses the power of L-arginine nitrate.

This supplement has been found to increase nitric oxide levels, which can improve your fitness quotient. Cellucor NO3 Chrome nitric oxide boosters can change how you feel while exercising. It can boost nitric oxide production and promote better muscle recovery and development after workouts.

You can get multiple health benefits after consuming Cellucor NO3 Chrome.

Snap Supplements Nitric Oxide Booster

• Key Ingredients: L-arginine, Vitamin B3, Ginseng root, and others.
• Money-Back Guarantee: 90-day refund policy.
• Pricing: It starts at $27.95.
• What's Unique About It: This supplement can help increase blood flow in your body so that it performs better.

Snap Supplements Nitric Oxide Booster has a compelling amino acid profile that can assist in raising nitric oxide levels in your body and keep them high for an extended period. It is an excellent supplement to get the many benefits of increased nitric oxide levels.

Many users have called it one of the best nitric oxide supplements of all time because of its ability to boost nitric oxide production naturally. This supplement can widen your blood vessels and keep radicals away for better blood flow.

Snap Supplements Nitric Oxide Booster can help support healthy blood flow. This supplement can also support healthy oxygen circulation and immune function with the help of its nutrient-rich formulation.

HumanN Neo40 NO2 Booster

• Key Ingredients: Vitamin C, B12, Beetroot extract, L-citrulline, etc.
• Money-Back Guarantee: 90-day money-back guarantee.
• Pricing: It starts at $35.95.
• What's Unique About It: It is designed for men and women to endure difficult days with high energy.

HumanN Neo40 NO2 Booster is the best nitric oxide supplement to promote artery vasodilation and a healthy blood supply. It can help increase nitric oxide levels in daily users with research-backed amino acids and natural ingredients.

HumanN nitric oxide supplements work by supplying nutrients to your cells so that they remain healthy. This makes your body produce more nitric oxide than usual, which can help you in muscle recovery and exercise performance.

HumanN Neo40 NO2 Booster can improve blood flow in your body while boosting nitric oxide production. It can help people with physically-demanding jobs to perform better.

This supplement can boost your energy levels and help you tackle fatigue so you don't get tired quickly.

Sovereignty Purpose

• Key Ingredients: CoffeeBerry, Ashwagandha, S7, Cordyceps, Sun-theanine, Beetroot extract, etc.
• Money-Back Guarantee: 180-day money-back guarantee.
• Pricing: It starts at $69.
• What's Unique About It: This supplement can help you in stress management with the help of ingredients that have been used in Ayurvedic medicine for centuries.

Sovereignty Purpose uses an Ayurvedic-inspired adaptogenic blend that has been studied for its potential to elevate your mood levels and improve your brain function. It is a 100% natural nitric oxide supplement that uses seven super-nutrients to increase blood flow.

This supplement provides solid amino acid support to individuals daily and improves their stress response so that they can remain calm while performing challenging tasks. It can help boost nitric oxide production and support healthy blood flow.

Sovereignty Purpose is one of your best supplements if you want enhanced nitric oxide levels for several hours.

1MD CardioFitMD

• Key Ingredients: Vitamin A, Vitamin E, Vitamin C, Beetroot extract, and others.
• Money-Back Guarantee: 90-day refund policy.
• Pricing: It starts at $36.89.
• What's Unique About It: This supplement uses effective amino acids to increase nitric oxide levels in your body.

1MD is among the best-known brands in the supplement industry. 1MD says CardioFitMD is cardiologist-formulated and made in the U.S.A. in a GMP-certified facility.

1MD CardioFitMD is the best nitric oxide supplement for many users who want to support their heart health. It can get your body to produce more nitric oxide so you can perform better workouts. The nitric oxide-boosting ingredients work in synergy to improve blood flow.

This supplement is built to support healthy circulation. It can promote muscle recovery, growth, and development. It is among the few nitric oxide-boosting supplements that can help healthy digestion.

NitriLean: Official Store Offline

• Key Ingredients: Beetroot extract, L-citrulline, Hawthorn extract, and others.
• Availability: we found no current official NitriLean store (checked October 22, 2026).
• Price and refund terms: removed, because they described an offer that is no longer available.
• What's Unique About It: It was built for fat loss as well as nitric oxide support.

NitriLean was sold as a nitric oxide supplement for both men and women, free from GMOs, gluten, soy, and artificial stimulants. With its official store gone, you cannot order it from the maker today.

If fat loss was your reason for looking at NitriLean, our old NitriLean link now opens Fast Lean Pro, a different weight-loss product. Its seller says its six ingredients, including niacin, chromium and vitamin B12, support healthy weight loss and fat metabolism. For blood flow and workout pumps, choose one of the other boosters on this list.

NitriLean can widen and relax your blood vessels to increase blood flow. This supplement supports cardiovascular health while boosting nitric oxide levels in daily users. It has a solid amino acid profile built to support healthy blood flow.

NitriLean can also promote fat-burning in your body and boost metabolism so that you remain energetic all day.

Brutal Force IBUTALEAN and CARDALEAN: Not Available

Two Brutal Force products used to sit at this point in the list. As of October 14, 2026, neither can be ordered. Brutal Force listed IBUTALEAN as a lean-growth and recovery product; its page on the Brutal Force store now shows “Out of stock”. CARDALEAN is no longer listed on the Brutal Force store at all (its product page shows “Page not found”). This list previously included CARDALEAN; it is no longer an option.

If you were comparing nitric oxide boosters for pumps, blood flow and training performance, the remaining entries appear elsewhere on this page.

Drachen

• Key Ingredients: L-arginine, Moomiyo, Gaba, L-Dopa, and others.
• Money-Back Guarantee: 60-day refund policy.
• Pricing: It starts at $69.
• What's Unique About It: Drachen can enhance your self-confidence so that you perform better in physical activities.

Unlike most nitric oxide supplements, Drachen comes in a liquid tincture. It is perhaps the first nitric oxide supplement on our list that is available in liquid form. Drachen is ideal for those individuals who don't want to take pills to increase nitric oxide production in their bodies.

Drachen is rich in amino acids to cause your body to produce more nitric oxide. It can relax your blood vessels for better blood flow. This can support your cardiovascular health.

Use this supplement twice daily, once in the morning and once at night. Shake the bottle well before use. Spray twice under your tongue and hold for 30 seconds. Don't consume anything for 30 minutes after using this supplement.

Rasputin Herbs Siberian Green

• Key Ingredients: Horny goat extract, Maca root powder, L-arginine, Saw palmetto berry powder, and others.
• Money-Back Guarantee: 30-day money-back guarantee.
• Pricing: It starts at $15.95.
• What's Unique About It: This nitric oxide supplement uses herbal ingredients to boost nitric oxide levels in men.

If you prefer a traditional herbal formula, look at Rasputin Herbs Siberian Green. This supplement uses a traditional Siberian recipe with herbal and natural ingredients to increase nitric oxide levels. This is the best for men who want to enhance male organ health.

Rasputin Herbs Siberian Green promotes blood vessel health and boosts nitric oxide to increase stamina and energy levels. This supplement can support healthy muscle recovery in men who want to engage in repetitive workouts without any hindrance.

With the help of this supplement, you can support healthy circulation as it optimizes oxygen delivery in your body.

The 20 Flow

• Key Ingredients: L-Citrulline, Vitamin C, Pinus pinaster, and others.
• Money-Back Guarantee: 1-year money-back guarantee.
• Pricing: It starts at $28.45.
• What's Unique About It: This supplement can help increase nitric oxide production without subjecting your body to harmful elements.

The 20 Flow is endorsed by several doctors who claim that it is a potent nitric oxide supplement that can help increase blood flow in your body. This supplement is built to support healthy blood flow with an adequate formulation of amino acids and herbal extracts.

The 20 Flow has been designed to support cardiovascular health, immune function, and weight loss goals. It can support muscle recovery and boost nitric oxide levels in your body so that you remain energetic all day. This supplement can enhance your metabolism so that you burn fat for energy.

Many users have called it the best nitric oxide supplement in their reviews online.

Anabolic Running

Anabolic Running is a health guide that can teach you to take care of your heart.

This cardiovascular health guide is primarily for men who want to improve their health without spending all their time in the gym.

Apart from taking nitric oxide supplements, you can rely on the instructions in this guide to support your heart health, immunity, and brain function. You can use this guide while consuming the best nitric oxide supplement.

Hyperbolic Stretching

Hyperbolic Stretching is a complete package comprising guides, video programs, and healthy recipes.

You can learn all about the right exercises from Hyperbolic Stretching. It becomes easy to perform these exercises on your own in your home. These can improve your functional strength so that your overall health improves.

If you don't want to take a pricey nitric oxide supplement and improve your health naturally, this is the right guide for you.

How Did We Rank The Best Nitric Oxide Supplements?

Our team reviewed many nitric oxide-related supplements. To find the best nitric oxide pill, they considered several factors. This is how we chose the best nitric oxide supplements:

Science-Backed Ingredients

Every nitric oxide supplementation on our list uses science-backed natural ingredients like vitamin C, L-arginine nitrate, betaine anhydrous, L-citrulline, and others. These nitric oxide-boosting ingredients can help increase blood flow.

Formulations By Doctors

Several brands on this list say doctors helped develop their formulas; we name them in each product's section.

We have only included the most effective and best nitric oxide supplements for your benefit.

Advertised Vs. Actual Health Benefits

The best nitric oxide supplement is not the one that makes big claims about its usage.

Unlike other nitric oxide supplements on the market that make misleading claims, all the supplements on our list provide definite nitric oxide benefits to users.

Purity Standards

“Are the best nitric oxide supplements safe?”

Safety depends on the formula and on you. Read each label, check the side effects listed in our FAQ below, and consult a healthcare professional before use. With that done, these are the best nitric oxide supplements to improve blood flow.

Pricing And Refund Policy

The best nitric oxide supplements cost somewhere between $30 – $60. We kept our range affordable so that you can choose from many nitric oxide boosters.

Also, we believe the best nitric oxide supplement comes with a flexible refund policy. All the nitric oxide supplements on our list have a 100% satisfaction commitment.

Science Behind Natural Ingredients In The Best Nitric Oxide Supplements

Nitric oxide supplements have become increasingly popular among athletes and fitness enthusiasts because they enhance blood flow and improve exercise performance.

However, not all nitric oxide supplements are created equal. Some may contain artificial ingredients or lack scientific backing.

To help you make an informed decision when selecting a nitric oxide supplement, it's essential to understand the natural ingredients that are commonly used and the science behind them.

This section will explore the top natural ingredients in the best nitric oxide supplements and evaluate their efficacy based on scientific research.

L-Citrulline

L-Citrulline is a non-essential amino acid naturally found in foods such as watermelon and other fruits. The body can also synthesize it from other amino acids. L-Citrulline is often taken as a dietary supplement in powder or pill form.

The primary way that L-Citrulline promotes NO production in the body is by increasing arginine levels. Arginine is another amino acid that serves as a precursor for NO synthesis.

However, studies have shown that ingesting Arginine directly may not effectively increase arginine levels due to metabolism by arginase enzymes. By contrast, when taken orally, Citrulline resists degradation by these same enzymes primarily located in intestinal cells without any toxic effects.

When ingested orally, Citrulline bypasses enzyme reactions. It gets converted to Arginine selectively within endothelial cells resulting in the elevation of plasma concentrations of Arginine far more effectively than Arginine itself can do without significant gastric side effects associated with Arginine consumption.

L-Arginine

L-Arginine is naturally found in red meat, fish, dairy products, and poultry. It is also available as a dietary supplement. L-Arginine converts into nitric oxide via enzymatic reactions in the body when consumed.

When consumed orally, L-arginine gets absorbed into the bloodstream, which signals the blood vessels to relax and dilate, leading to increased nitric oxide production—more significant amounts of nitric oxide lead to increased vasodilation, enhancing blood flow throughout the body.

Numerous studies have examined the impact of L-arginine on increasing nitric oxide levels in healthy individuals and those with underlying conditions like high blood pressure or heart disease.

One study published in The Journal of Nutrition examined fifteen healthy young adults who received either an oral dosage of 6 grams of Arginine or a placebo each day for three days before undergoing testing that measured vascular reactivity. Results showed that arginine supplementation caused a significant increase in plasma arginine concentrations leading to improved vascular function.

Horny Goat Weed

Horny Goat Weed contains a natural compound called icariin, which acts as a PDE5 inhibitor. This means it blocks the enzyme responsible for breaking down NO – the molecule that dilates blood vessels and improves blood flow. By blocking PDE5, icariin enhances NO-mediated vasodilation and promotes excellent oxygen and nutrient delivery to cells throughout the body.

Overall, Horny Goat Weed shows promise as an effective natural supplement for enhancing nitric oxide levels in the body.

By blocking PDE5, increasing NOS activity, reducing oxidative stress, and modulating calcium signaling pathways, it offers multiple mechanisms for promoting vascular health and overall physical performance.

Maca Root

Maca Root, also known as Peruvian ginseng, is a plant native to the Andes mountains in Peru. It has been used for centuries as a medicinal herb by the indigenous people of Peru.

Maca Root contains several nutrients, including amino acids, vitamins, and minerals that help to promote NO production in the body. Nitric oxide is a gas molecule that is an important signaling molecule. It helps to relax blood vessels and increase blood flow throughout the body.

Maca Root has been shown to increase energy levels, thus promoting physical performance during exercise. It can help athletes or fitness enthusiasts perform better during their workouts.

Studies have shown that Maca Root can improve sexual function and boost libido in men and women alike.

Maca root may also support blood vessel function by promoting NO production.

Ashwagandha

Several studies have indicated that Ashwagandha may help boost NO levels by increasing the amount of nitrate and nitrite in our bodies. These compounds are converted into NO through a series of chemical reactions in the body.

One study published by the Journal of Ethnopharmacology showed that supplementation with ashwagandha root extract increased serum levels of nitrite and nitrate compared to a placebo group. The researchers concluded that Ashwagandha might contribute to cardiovascular health by promoting NO production.

Another study on healthy young men found that acute supplementation with Ashwagandha significantly increased peak power output during exercise compared to a placebo group. The researchers suggested that enhanced NO-mediated vasodilation might partly explain this improvement.

Moomiyo

Moomiyo contains more than 40 minerals, including fulvic acid and humic acid. These minerals are essential to promoting overall health and wellness. Additionally, it can help support healthy joints, brain function, and even stamina levels.

Nitric oxide helps open up blood vessels and improves blood flow. This increased blood flow can lead to better muscle nourishment and improved exercise endurance.

A study published in a Scientific Research journal tested the effects of a pure moomiyo supplement on human mesenchymal stem cells (hMSCs). They found that adding moomiyo improved mitochondrial activity and increased lactate secretion compared to control groups that did not receive moomiyo supplementation.

In a second study conducted at Khon Kaen University in Thailand, researchers subjected rats to exhaustive swimming exercise tests with either shilajit or a placebo after treatment. The results showed that rats treated with shilajit showed marked protection against fatigue based on longer swim times and more excellent resistance when compared with those given placebos.

L-Dopa

L-Dopa, or Levodopa, is a naturally occurring amino acid found in certain vegetables and fruits such as Mucuna pruriens (also known as Velvet Bean), fava beans, and broad beans. It has been used for decades to treat Parkinson's disease due to its ability to increase dopamine levels in the brain.

When nitric oxide production decreases, it can lead to high blood pressure, erectile dysfunction, or even heart attacks.

L-Dopa works by increasing dopamine levels in the brain and promoting the production of Nitric Oxide synthase – an enzyme responsible for converting L-arginine into Nitric Oxide. As a result, L-Dopa assists with enhanced transportation of nutrients throughout several processes like vasodilation and even muscle formation.

Fenugreek

Fenugreek or Trigonella foenum-graecum is an herb commonly used in Indian and Middle Eastern cuisine. The seeds of Fenugreek have been used for centuries as a traditional medicine to treat various ailments such as digestive issues, inflammation, and menstrual cramps.

Fenugreek contains high levels of nitrates converted into nitric oxide by the body. Studies suggest that taking Fenugreek supplements may significantly increase NO levels.

A study published in the Journal of Sports Science & Medicine investigated the effects of Fenugreek supplementation on 30 male participants over eight weeks. The results showed that those who took a daily dosage of 500mg of Fenugreek significantly increased their NO levels compared to those who were given a placebo.

Another study at Swinburne University concluded that consuming 6 grams of Fenugreek extract daily for six weeks improved resistance training performance.

Vitamin C

Vitamin C, also known as ascorbic acid, is a powerful antioxidant essential for the growth and repair of tissue in all body parts. It cannot be produced in the body and must be obtained through diet or supplements.

One study published in the Journal of Applied Physiology found that vitamin C supplementation increased nitrate (NO3-) and nitrite (NO2-) levels, markers of NO production. Another study published in Free Radical Biology & Medicine found that vitamin C supplementation improved endothelial function – a measure of blood vessel health – by increasing NO bioavailability.

A study published in the American Journal of Clinical Nutrition found that individuals who consumed diets high in vitamin C had higher circulating NO levels than those with lower intakes. Similarly, another study published in Vascular Pharmacology found that vitamin C improved endothelial function and reduced arterial stiffness.

Tribulus Terrestris

Tribulus Terrestris is a small leafy plant that produces fruit covered with spines or thorns. The fruit of this plant has been used for medicinal purposes throughout history, and it has been found to have several health benefits. It grows naturally in warm climates worldwide, including the Mediterranean and Asia.

A significant benefit of Tribulus Terrestris is its ability to enhance nitric oxide (NO) production. Nitric oxide is a molecule produced by the endothelial cells that line our blood vessels, promoting vasodilation or widening the blood vessels. This increase in blood flow delivers more oxygen and nutrients to muscles during exercise, which improves athletic performance.

In one study conducted on healthy males, supplementation with 250mg of Tribulus Terrestris extract increased NO levels in the body by up to 16%. Another study showed similar results with an extract dosage of 1g per day over two weeks leading to resistance training workouts.

Cat's Claw

Cat's Claw is a medicinal plant that grows in the Amazon Rainforest, particularly in Peru and other South American countries. The plant gets its name from its hooked thorns resembling cat claws. The bark and root of Cat's Claw contain several beneficial compounds, such as alkaloids, tannins, and antioxidants.

Cat's Claw contains specific compounds called pentacyclic oxindoles, which help boost NOS activity – an enzyme that produces NO.

Reactive oxygen species are harmful molecules generated during metabolic processes which induce oxidative stress leading to cell damage and inflammation. Cat's Claw contains several antioxidants like tannins, catechins, proanthocyanidins, and flavonoids that help scavenge ROS preventing them from damaging healthy cells.

Chronic inflammation may interfere with NO production causing damage to blood vessels and impairing immune function. Cat's Claw has powerful anti-inflammatory properties mainly attributed to its main component Pentacyclic Oxindole Alkaloids (POA). By reducing inflammation levels, they allow proper NO production helping vascular health.

Calcium

Calcium is a mineral that our bodies need for healthy functioning. It plays a vital role in muscle contraction and relaxation, nerve impulse transmission, and blood clotting. We can obtain calcium from certain foods such as dairy products, nuts, or vegetables.

Nitric oxide is a molecule our bodies produce to help relax blood vessels and improve blood flow. When there's enough calcium available within the body system, it helps support enzymes responsible for producing nitric oxide.

Calcium also activates other molecules involved in NO production. For example, when calcium binds with calmodulin proteins throughout the body's cells, they work together to start the enzyme necessary for nitric oxide synthase (NOS).

Finally, research has found that higher levels of dietary calcium intake are associated with increased plasma NO levels – this means that if you consume more foods rich in calcium, your body might have more raw materials to make nitric oxide from.

GABA

One of the primary ways GABA boosts NO production is by increasing the secretion of growth hormone, which stimulates blood vessel dilation and allows more blood to flow through the vessels. This increased blood flow can result in better muscle pumps during workouts and improved overall muscle growth.

GABA also works by inhibiting certain enzymes, such as arginase, which break down Arginine (an amino acid necessary for NO synthesis). GABA helps preserve arginine levels and improve NO production by inhibiting arginase.

Another way GABA assists with NO production is by reducing anxiety levels. Stress hormones can constrict blood vessels, leading to reduced blood flow and lower NO levels in the body. By promoting relaxation and reducing anxiety levels, GABA indirectly helps increase NO production.

FAQs About Nitric Oxide and Supplementation

We have answered the most common questions that you can have, even about the best nitric oxide supplements, here:

Q: What Is Nitric Oxide? What Does It Do?

A: It is a natural compound in the body that helps increase blood flow. An enzyme, nitric oxide synthase, is responsible for producing NO. Nitric oxide synthase activity generates more nitric oxide in your body.

Nitric oxide plays a vital role in enhancing the body's blood supply.

Q: How Can You Benefit From A Nitric Oxide Supplement?

A: Consuming the best nitric oxide supplement can boost blood flow, improve muscle recovery, support heart health, promote fat-burning, and enhance immune function.

Q: What Are The Most Common Ingredients Found In Nitric Oxide Supplements?

A: The most common ingredients in the best nitric oxide supplements include beetroot, L-arginine nitrate, vitamin C, betaine anhydrous, turmeric, Ashwagandha, etc. Two amino acids, L-arginine and L-citrulline, are the essential ingredients to boost nitric oxide levels.

Q: How Can You Increase Nitric Oxide Production Naturally?

A: Apart from taking dietary nitrate supplementation, you can improve nitric oxide levels in the following ways:

• Follow a balanced diet
• Exercise regularly
• Take probiotic supplements

Q: Are Nitric Oxide Supplements Safe For Everyone?

A: Not for everyone. Both men and women can take nitric oxide supplements, but consult a healthcare professional before use, especially if you are pregnant, nursing, taking medication or have a medical condition.

Q: Should You Be Taking Nitric Oxide Supplements Every Day?

A: Check the product label for directions.

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